1962 — The Cold War continues as a new threat looms on the horizon, a deadly new Soviet bioweapon, something called "Project MEDUSA". You and your fellow medical graduates have been recruited by the CIA for the critical mission of investigating and preventing its development. Travel the world using carefully constructed aliases to move swiftly between Allied, Neutral, and Soviet cities. Your missions will require you to neutralize enemy agents, acquire specific targets, and set up other CIA agents on location to execute your operations without a hitch. As you complete objectives over the course of twelve months, each success or failure will bring you closer to the truth.

Designed as a prequel, Pandemic Legacy: Season 0 does not require you to have completed Season 1 and Season 2 before diving into this Cold War spy thriller. As in the first two Pandemic Legacy games, each time you play brings new cards, rules, and conditions that affect future games. Each alias you create will gain contacts and other assets to execute your plans more smoothly. And, of course, the CIA will be watching and evaluating your performance in the field. Work together with your fellow agents to prevent this new bio-threat — the fate of the world depends on it. Can you save humanity once again?